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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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10 hot topic(s) found with the query "Neurological disorders"

Shared mechanisms across the major psychiatric and neurodegenerative diseases
TS Wingo et al, Nat Comm, July 26, 2022 (Posted: Jul 26, 2022 7AM)

Using 25 GWAS results and LD score regression, we find eight significant genetic correlations between psychiatric and neurodegenerative diseases. We integrate the GWAS results with human brain transcriptomes (n?=?888) and proteomes (n?=?722) to identify cis- and trans- transcripts and proteins that are consistent with a pleiotropic or causal role in each disease, referred to as causal proteins for brevity. Within each disease group, we find many distinct and shared causal proteins. Remarkably, 30% (13 of 42) of the neurodegenerative disease causal proteins are shared with psychiatric disorders.

The value of genomic sequencing in complex pediatric neurological disorders: a discrete choice experiment.
Goranitis Ilias et al. Genetics in medicine : official journal of the American College of Medical Genetics 2020 Aug (Posted: Aug 26, 2020 7AM)

On average, society highly values all diagnostic, process, clinical, and nonclinical components of personal utility. To ensure fair prioritization of genomics, decision makers need to consider the wide range of risks and benefits associated with genomic information.

The Polygenic Score Catalog: an open database for reproducibility and systematic evaluation
SA Lambert et al, MEDRXIV, May 23, 2020 (Posted: May 24, 2020 7AM)

We present the PGS Catalog (www.PGSCatalog.org), an open resource for polygenic scores. The PGS Catalog currently contains 192 published PGS from 78 publications for 86 diverse traits, including diabetes, cardiovascular diseases, neurological disorders, cancers, as well as traits like BMI and blood lipids.

DNA sequencing study suggests common genetic basis for epilepsy
by Abbey Bigler, Broad Institute, July 23, 2019 (Posted: Jul 25, 2019 10AM)

Epilepsy is one of the most widespread neurological disorders, but relatively little is known about the genes involved in the more common types. By examining all the genes of over 17,000 people, an international research group has found that more and less severe forms of epilepsy may share similar genetic features.

Gene therapy for neurological disorders: progress and prospects
BE Deverman et al, Nature Rev Drug Discovery, AUgust 10, 2018 (Posted: Aug 10, 2018 8AM)

Antisense oligonucleotides: the next frontier for treatment of neurological disorders.
Rinaldi Carlo et al. Nature reviews. Neurology 2017 Dec (Posted: Dec 11, 2017 8PM)

Genetic signatures in ischemic stroke: Focus on aspirin resistance.
Munshi Anjana et al. CNS & neurological disorders drug targets 2017 Oct (Posted: Oct 19, 2017 2PM)

What is Tay-Sachs Disease?
Information from the National Institute for Neurological Disorders and Stroke Brand (Posted: Dec 29, 2015 8PM)

Rett Syndrome Fact Sheet
National Institute of Neurological Disorders and Stroke Brand (Posted: Mar 04, 2015 9AM)

Preimplantation genetic diagnosis for inherited neurological disorders.
Tur-Kaspa Ilan et al. Nat Rev Neurol 2014 Jul (7) 417-24 (Posted: Feb 23, 2015 10AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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